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Women's Health Initiative: Dietary Modification Trial

Study characteristics: 1) 48,835 women, postmenopausal, mean age 62 2) no breast or colon cancer, 3% with cardiovascular disease 2) mean follow-up 8 years Groups: low fat diet (20% fat) vs regular diet No stratification based on type of fat Outcome: 1) breast cancer or colorectal cancer 2) acute coronary syndrome, myocardial infarction 3) stroke 4) weight change Results: - NO difference in any outcome in the 2 groups, except low fat diet maintained lower weight than control group

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Women's Health Initiative (WHI)

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clinical trial

References

  1. Prenctice RL et al, Low-fat dietary pattern and risk of invasive breast cancer: The Women's Health Initiative Randomized Controlled Dietary Modificaton Trial, JAMA 2006, 295:629 PMID: 16467232
  2. Beresford SAA et al, Low-fat dietary pattern and risk of invasive colorectal cancer: The Women's Health Initiative Randomized Controlled Dietary Modificaton Trial, JAMA 2006, 295:643 PMID: 16467233
  3. Howard BV et al, Low-fat dietary pattern and risk of cardiovascular disease: The Women's Health Initiative Randomized Controlled Dietary Modificaton Trial, JAMA 2006, 295:655 PMID: 16467234
  4. Howard BV et al, Low-fat dietary pattern and weight change over 7 years: The Women's Health Initiative Randomized Controlled Dietary Modificaton Trial, JAMA 2006, 295:39 PMID: 16391215